Cgc Grade
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 AMAZING SPIDER MAN 10 CGC 90 UNIVERSAL HIGH GRADE UNRESTORED $1,600.00 Time Remaining: 8d 18h 33m Buy It Now for only: $1,600.00 |
 NYX 3 CGC 98 FIRST X 23 RARE HIGH GRADE $215.00 Time Remaining: 1d 20h 37m Buy It Now for only: $275.00 |
 X MEN 94 CGC GRADE 85 $350.00 (1 Bid) Time Remaining: 1d 10h 31m |
 X MEN 50 CGC GRADE 98 HOT ITEM HOT TITLE $60.00 Time Remaining: 8d 17h 55m Buy It Now for only: $60.00 |
 INCREDIBLE HULK 158 CGC 94 HARD TO FIND IN GRADE $129.99 Time Remaining: 1d 18h 35m |
 AMAZING SPIDER MAN 122 CGC 98 OFF WHITE TO WHITE PAGES BEST CGC GRADE GOBLIN $2,600.00 Time Remaining: 29d 10h 34m Buy It Now for only: $2,600.00 |
 The Amazing Spider Man Issue 9 CGC Grade 90 $2,100.00 Time Remaining: 1d 13h 48m Buy It Now for only: $2,400.00 |
 THE WALKING DEAD 11 First Printing CGC 98 Top Grade NO RESERVE $22.50 (7 Bids) Time Remaining: 3d 15h 17m |
 THIEF OF THIEVES 1 1ST PRINT CGC 98 INVESTMENT GRADE $425.95 Time Remaining: 19d 19h 26m Buy It Now for only: $425.95 |
 THE WALKING DEAD 12 First Printing CGC 98 Top Grade NO RESERVE $26.00 (7 Bids) Time Remaining: 3d 15h 34m |
 DC COMICS DETECTIVE 576 WITH CGC 98 GRADE $45.00 Time Remaining: 10d 12h 49m Buy It Now for only: $45.00 |
 THE WALKING DEAD 14 First Printing CGC 98 Top Grade NO RESERVE $30.00 (30 Bids) Time Remaining: 3d 17h 41m |
 THE WALKING DEAD 18 First Printing CGC 98 Top Grade NO RESERVE $14.38 (9 Bids) Time Remaining: 3d 18h 28m |
 Talse of Suspense 52 CGC 80 1st Appearance Black Widow CURRENTLY HIGHEST GRADE $1,000.00 Time Remaining: 29d 14h 8m Buy It Now for only: $1,000.00 |
 THE WALKING DEAD 25 First Printing CGC 98 Top Grade NO RESERVE $20.50 (10 Bids) Time Remaining: 3d 19h 14m |
 Wolverine Limited 2 Oct 82 CGC Graded NM 94 High Grade Miller Art $60.00 Time Remaining: 7d 11m Buy It Now for only: $60.00 |
 Invincible Iron Man 23 Deadpool Variant CGC 98 TOUGH high grade issue $29.99 (1 Bid) Time Remaining: 15h 46m |
 FAMOUS MONSTERS OF FILMLAND 30 1964 CGC VF+ 85 VERY SCARCE IN HIGH GRADE $249.99 Time Remaining: 5d 18h 14m |
 Wolverine Limited Series 1 CGC Grade 96 $100.00 Time Remaining: 4d 12h 52m Buy It Now for only: $100.00 |
 THE WALKING DEAD 10 First Printing CGC 98 Top Grade NO RESERVE $78.00 (13 Bids) Time Remaining: 3d 13h 7m |
 FANTASTIC FOUR 44 CGC GRADE 85 $145.00 Time Remaining: 26d 9h 26m Buy It Now for only: $145.00 |
 THE WALKING DEAD 3 First Printing CGC 96 Top Grade NO RESERVE $41.00 (10 Bids) Time Remaining: 5d 1h 21m |
 FAMOUS MONSTERS OF FILMLAND 38 1966 CGC VF 80 VERY SCARCE IN HIGH GRADE $299.99 Time Remaining: 5d 18h 20m |
 CGC 94 Amazing Spider Man 168 High Grade WhitePages $69.99 Time Remaining: 29d 20h 47m Buy It Now for only: $69.99 |
 THE WALKING DEAD 66 First Printing CGC 98 Top Grade NO RESERVE $4.13 (5 Bids) Time Remaining: 5d 1h 22m |
 CGC 94 Amazing Spider Man 177 High Grade WhitePages $79.99 Time Remaining: 29d 20h 47m Buy It Now for only: $79.99 |
 THE WALKING DEAD 67 First Printing CGC 98 Top Grade NO RESERVE $3.63 (4 Bids) Time Remaining: 5d 1h 23m |
 THE WALKING DEAD 60 First Printing CGC 98 Top Grade NO RESERVE $16.50 (6 Bids) Time Remaining: 5d 1h 24m |
 CGC 96 Amazing Spider Man 191 High Grade WhitePages $89.99 Time Remaining: 29d 20h 48m Buy It Now for only: $89.99 |
 THE WALKING DEAD 62 First Printing CGC 98 Top Grade NO RESERVE $6.00 (6 Bids) Time Remaining: 5d 1h 25m |
 CGC 96 Amazing Spider Man 192 High Grade WhitePages $89.99 Time Remaining: 29d 20h 48m Buy It Now for only: $89.99 |
 FANTASTIC FOUR 80 Vintage Old Silver Age CGC MOVIE Kirby HIgh Grade $14.99 Time Remaining: 1d 21h 50m |
 MASTER OF KUNG FU Issue 53 Slabbed and graded by Cgc 96 Guaranteed High Grade $16.50 (6 Bids) Time Remaining: 1d 17h 6m |
 Wolverine Limited 4 Dec 82 CGC Graded NM 94 High Grade Miller Art $60.00 Time Remaining: 7d 13m Buy It Now for only: $60.00 |
 TALES OF SUSPENSE 97 HIGH GRADE MARVEL COMIC CGC IT $49.95 Time Remaining: 1d 17h 26m Buy It Now for only: $60.00 |
 CGC 96 X Men 267 White PagesHigh Grade $39.99 Time Remaining: 29d 20h 49m Buy It Now for only: $39.99 |
 THOR 159 CGC graded 90 BONE WHITE PAGES 1968 HIGH GRADE BEAUTY $0.99 (1 Bid) Time Remaining: 5d 22h 35m |
 THE WALKING DEAD 65 First Printing CGC 98 Top Grade NO RESERVE $6.50 (6 Bids) Time Remaining: 5d 1h 23m |
 AMAZING SPIDER MAN 5 CGC 90 UNIVERSAL HIGH GRADE UNRESTORED $4,100.00 Time Remaining: 5d 18h 36m Buy It Now for only: $4,100.00 |
 KISS COMIC MARVEL SUPER SPECIAL WITH KISS POSTER IN HI GRADE CGC IT $119.95 Time Remaining: 1d 10h 8m Buy It Now for only: $140.00 |
 CGC 96 X Men 211 White PagesHigh Grade $51.99 Time Remaining: 29d 20h 49m Buy It Now for only: $51.99 |
 X MEN 48 SILVER AGE MARVEL COMIC 1968 NEW COSTUMES HIGH GRADE CGC IT $89.95 Time Remaining: 1d 20h 42m Buy It Now for only: $110.00 |
 AMAZING SPIDER MAN 146 CGC 98 RARER TOP GRADE GREAT CENTERING $599.99 Time Remaining: 1d 20h 1m Buy It Now for only: $660.00 |
 FANTASTIC FOUR 1 1961 Marvel Comics CGC Grade 5 $1,250.00 Time Remaining: 20d 15h 37m Buy It Now for only: $1,250.00 |
 STRANGE TALES 133 CGC graded 80 OW TO WHITE PAGES 1965 HIGHER GRADE $1.04 (2 Bids) Time Remaining: 5d 22h 40m |
 Runaways 3 CGC 98 2005 Highest Grade Only 3 98 $49.99 Time Remaining: 14d 12h 19m Buy It Now for only: $49.99 |
 NEW MUTANTS 98 1ST DEADPOOL HIGH GRADE MARVEL COMIC CGC THIS ONE $110.95 Time Remaining: 1d 11h 33m Buy It Now for only: $125.00 |
 Avengelyne Swimsuit Edition 1 CGC 98 Highest Grade $75.00 Time Remaining: 2d 23h 50m |
 BATMAN 43 CGC NM 92 Highest CGC Grade PENGUIN Never Pressed Gem 1947 $4,295.00 Time Remaining: 7d 12h 37m Buy It Now for only: $4,295.00 |
 Captain Marvel 2 High Grade Super Skrull send it to CGC $60.00 Time Remaining: 1d 23h 51m Buy It Now for only: $85.00 |
 CGC 96 GIJoe 42 High GradeWhite Pages $27.99 Time Remaining: 29d 20h 48m Buy It Now for only: $27.99 |
 MARVEL PREMIERE 58 CGC 98 HIGHEST GRADE DOCTOR WHO $39.00 Time Remaining: 1d 21h 10m |
 Strange Tales Annual 1 CGC 80 HIGH GRADE PRE SUPERHERO MARVEL $399.99 Time Remaining: 5d 20h 2m |
 CGC 96 GIJoe 59 High GradeWhite Pages $36.99 Time Remaining: 29d 20h 48m Buy It Now for only: $36.99 |
 X MEN 40 SILVER AGE MARVEL COMIC 1968 FRANKENSTEIN COVER HIGH GRADE CGC IT $99.95 Time Remaining: 1d 20h 42m Buy It Now for only: $120.00 |
 CGC 96 GIJoe 128 High GradeWhite Pages $41.99 Time Remaining: 29d 20h 48m Buy It Now for only: $41.99 |
 X MEN 45 SILVER AGE MARVEL COMIC 1968 HIGH GRADE CGC IT $69.95 Time Remaining: 1d 20h 42m Buy It Now for only: $99.00 |
 FANTASTIC FOUR 56 CGC graded 85 OW WHITE PAGES 1966 KLAW AND DOOM HI GRADE $0.99 (1 Bid) Time Remaining: 5d 22h 57m |
 CGC 96 GIJoe 46 High GradeWhite Pages $39.99 Time Remaining: 29d 20h 48m Buy It Now for only: $39.99 |
 DEFENDERS 77 98 CGC HIGHEST GRADE ONLY 7 IN 98 HULK $49.00 Time Remaining: 1d 21h 10m |
 CGC 96 GIJoe 58 High GradeWhite Pages $41.99 Time Remaining: 29d 20h 48m Buy It Now for only: $41.99 |
 DEFENDERS 73 98 CGC HIGHEST GRADE ONLY 7 IN 98 HULK $49.00 Time Remaining: 1d 21h 10m |
 DEFENDERS 71 98 CGC HIGHEST GRADE ONLY 9 IN 98 HULK $49.00 Time Remaining: 1d 21h 10m |
 BATMAN 1 CGC VF 80 Near White Pages Beautiful High Grade 1940 Original $27,295.00 Time Remaining: 18d 11h 59m Buy It Now for only: $27,295.00 |
 DEFENDERS 84 98 CGC HIGHEST GRADE ONLY 7 IN 98 HULK $49.00 Time Remaining: 1d 21h 10m |
 Daredevil 1 VF 80 and 3 CGC 92 7 What a Lot High Grade WoW over 5000 Value $2,999.99 Time Remaining: 27d 9h 4m Buy It Now for only: $2,999.99 |
 ADVENTURE COMICS 303 CGC graded 75 CR OW PAGES 1962 HIGHER GRADE SUPERBOY $0.99 Time Remaining: 5d 22h 22m |
 DEFENDERS 69 98 CGC HIGHEST GRADE ONLY 10 IN 98 HULK $49.00 Time Remaining: 1d 21h 10m |
 Night Nurse 4 CGC 96 White Pgs Scarce Last Issue Top Grade $675.00 Time Remaining: 18d 13h 17m Buy It Now for only: $675.00 |
 DEFENDERS 72 98 CGC HIGHEST GRADE ONLY 6 IN 98 HULK $49.00 Time Remaining: 1d 21h 10m |
 CAPTAIN AMERICA 277 CGC 98 1983 WHITE PAGES BEST CGC GRADE $50.00 Time Remaining: 17d 16h 31m Buy It Now for only: $50.00 |
 CAPTAIN AMERICA 267 98 CGC HIGHEST GRADE MARVEL 1982 $49.00 Time Remaining: 1d 21h 10m |
 AMAZING SPIDER MAN 133 CGC 98 MOLTEN MAN TOP GRADE $399.99 Time Remaining: 1d 19h 52m Buy It Now for only: $499.99 |
 Wolverine 3 CGC 85 UNIVERSAL GRADE $29.99 Time Remaining: 28d 15h 7m Buy It Now for only: $29.99 |
 STARTLING 2 CGC VG F 50 BETTER PUBS 1940 NO RESERVEOWP 2ND HIGHEST GRADE $399.00 Time Remaining: 7d 3h 32m |
 Daredevil 7 First Red Suit CGC 92 looks NM+ 94 96 Rare Grade Hard Blue Cover $2,499.99 Time Remaining: 28d 8h 29m Buy It Now for only: $2,499.99 |
 X MEN 41 SILVER AGE MARVEL COMIC 1968 HIGH GRADE CGC IT $69.95 Time Remaining: 1d 20h 42m Buy It Now for only: $99.00 |
 X MEN 47 SILVER AGE MARVEL COMIC 1968 HIGH GRADE CGC IT $99.95 Time Remaining: 1d 20h 42m Buy It Now for only: $120.00 |
 AMAZING SPIDER MAN 4 CGC 85 UNIVERSAL VF+ HIGH GRADE UNRESTORED $3,900.00 Time Remaining: 8d 18h 35m Buy It Now for only: $3,900.00 |
 FLAMING CARROT 3 96 CGC HIGHEST GRADE ONLY 1 96 CGC $149.95 Time Remaining: 1d 21h 10m |
 DC Adventure COMICS THE SPECTRE RETURNS 432 CGC UNIVERSAL GRADE 60 $42.99 Time Remaining: 29d 15h 1m Buy It Now for only: $42.99 |
 Detective Comics 8 47 126 Rare Penguin Cover CGC Restored Grade 85 $400.00 Time Remaining: 2d 9h 59m |
 WARRIORS OF PLASM 1 98 CGC WHITE PAGES HIGHEST GRADE $24.95 Time Remaining: 1d 21h 10m |
 Looney Tunes 27 GK Aug 79 No CGCs Investment Grade $21.50 Time Remaining: 29d 13h 46m Buy It Now for only: $21.50 |
 Lil Abner 66 CGC VF NM 90 High Grade $89.95 Time Remaining: 1d 11h 4m |
 Transmetropolitan 1 2 3 ALL NM Mint 1st Prints High CGC Grade $54.99 Time Remaining: 6d 23h 21m Buy It Now for only: $54.99 |
 WARLORD 7 CGC 98 NM MT HIGHEST GRADE WHITE PAGES ONLY 4 OTHERS IN 98 CGC $99.95 Time Remaining: 1d 21h 10m |
 Carnage Marvel 1 Variation C 96 CGC Grade $59.99 Time Remaining: 16h 17m |
 DC COMICS BATMAN 608 WITH CGC 98 GRADE $65.00 Time Remaining: 11d 14h 4m Buy It Now for only: $65.00 |
 X Men 82 CGC 92 hi grade silver age White Pages $199.99 Time Remaining: 1d 21h 35m |
 Spider Man 29 CGC 98 Highest Grade 1992 White Pages Mad Dog Ward Part 1 $19.99 Time Remaining: 14d 11h 26m Buy It Now for only: $19.99 |
 X MEN 100 Marvel High Grade Nm Mt Cgc 98 White Pages Smith Variant Scarce $120.00 Time Remaining: 1d 18h 26m Buy It Now for only: $132.00 |
 X MEN 100 Marvel High Grade Nm Mt Cgc 98 White Pages Yu Variant Scarce $120.00 Time Remaining: 1d 18h 26m Buy It Now for only: $132.00 |
 Thor Comic 337 CGC 98 1st Beta Ray Bill High Grade WP $149.95 Time Remaining: 20d 21h 59m Buy It Now for only: $149.95 |
 TRANSFORMERS 61 CGC 98 1ST UNICRON HARD TO FIND TOP GRADE $59.99 Time Remaining: 1d 19h 46m Buy It Now for only: $79.99 |
 CGC 94 Amazing Spider Man 155 High Grade WhitePages $99.99 Time Remaining: 29d 20h 47m Buy It Now for only: $99.99 |
 AMAZING SPIDER MAN 141 CGC 98 WHITE PAGES TOP GRADE First Mysterio II $349.99 Time Remaining: 1d 19h 59m Buy It Now for only: $399.99 |
 X MEN 39 SILVER AGE MARVEL COMIC 1967 NEW COSTUMES HIGH GRADE CGC IT $129.95 Time Remaining: 1d 20h 42m Buy It Now for only: $145.00 |
 CGC UNIVERSAL GRADE 55 KEY 1st ISSUE CAPTAIN AMERICA 100 MARVEL COMICS 4 68 $350.00 Time Remaining: 23h 26m Buy It Now for only: $350.00 |
 THE WALKING DEAD 8 First Printing CGC 98 Top Grade NO RESERVE $36.00 (4 Bids) Time Remaining: 3d 12h 26m |
Cgc Grade
Spontaneous Humoral Immune Response to Mesothelin in Humans
One interesting study is called, "Humoral Immune Response to Mesothelin in Mesothelioma and Ovarian Cancer Patients" by Mitchell Ho, Raffit Hassan, Jingli Zhang, Qing-cheng Wang, Masanori Onda, Tapan Bera and Ira Pastan - Clinical Cancer Research May 2005 – Here is an excerpt: "Abstract - Purpose: Mesothelin is a glycosyl-phosphatidylinositol–anchored glycoprotein present on the cell surface. Mesothelin is a differentiation antigen that is highly expressed on mesothelioma, ovarian cancer, and pancreatic cancer. The existence of a spontaneous humoral immune response to mesothelin in humans has not been fully studied. Here we addressed the issue of whether mesothelin elicits a humoral immune response in patients with mesothelioma and ovarian cancer.
Experimental Design: Using an ELISA, we analyzed immunoglobulin G antibodies specific for mesothelin in sera from patients with mesothelioma and epithelial ovarian cancer. Tumor specimens were examined by immunohistochemistry for mesothelin protein expression.
Results: Elevated levels of mesothelin-specific antibodies were detected in the sera of 39.1% of patients with mesothelioma (27 of 69 patients) and 41.7% with epithelial ovarian cancer (10 of 24 patients) when compared with a normal control population (44 blood donors; P < 0.01 for both mesothelioma and ovarian cancer). We also found that 53% to 56% of patients with mesothelin immunostaining-positive mesothelioma and ovarian cancer had antibodies specific for mesothelin, whereas only 0% to 8% of patients with negative mesothelin immunostaining had detectable mesothelin-specific antibodies (χ2 test: P < 0.01 for mesothelioma and P = 0.025 for ovarian cancer).
Conclusions: Our findings indicate that mesothelin is a new tumor antigen in patients with mesothelioma and ovarian cancer and the immunogenicity of mesothelin is associated with its high expression on the tumor cells. Mesothelin represents an excellent target for immune-based therapies."
Another interesting study is called, "Low Incidence of Point Mutations in H-, K- and N-ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate" by Yasuyuki Nishiyama, Hirofumi Suwa, Keisei Okamoto, Manabu Fukumoto, Hiroshi Hiai, Shinya Toyokuni - Cancer Science Volume 86, Issue 12, pages 1150–1158, December 1995. Here is an excerpt: "An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage, a consequence of iron-catalyzed free radical reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Previous studies have identified, within 24 h after administration of Fe-NTA, lipid peroxidation products, aldehyde-modified proteins and a variety of modified DNA bases such as 8-hydroxyguanine that may be mutagenic in vivo. In the present study, pathological features of the RCCs were studied, and, in an effort to correlate them with carcinogen-specific molecular events in Fe-NTA-induced carcinogenesis, the H-, K- and N-ras oncogenes and the p53 tumor suppressor gene were investigated for the presence of mutations. Fe-NTA-induced RCCs showed similarity to human RCCs in that they are often invasive, metastatic and fatal. None (0 of 12) of the tumors had mutation in codons 12, 13 and 61 of the H-, K- and N-ras genes by direct sequencing. Only one (1 of 12) tumor with high grade histology revealed a CGC-to-CTC (Arg to Leu) transversion in codon 246 of the p53 gene by the use of single strand conformation polymorphism (SSCP) analysis and direct sequencing. High expression of mutant p53 protein was confirmed by Western blotting and immunohistochemistry. Study of three peritoneal mesotheliomas induced by Fe-NTA revealed no mutation in ras and p53 genes. These results suggest that the ras and p53 genes are not the major targets of mutation in Fe-NTA-induced carcinogenesis of kidney and mesothelium. Instead, p53 mutation may work for potentiation of malignant character in Fe-NTA-induced renal carcinogenesis."
Another interesting study is called, "Virchows Archiv B Cell Pathology Zell-pathologie" - Volume 52, Number 1, 55-65 Simultaneous immunoenzyme staining of vimentin and cytokeratins with monoclonal antibodies as an aid in the differential diagnosis of malignant mesothelioma from pulmonary adenocarcinoma by H. Mullink, S. C. Henzen-Logmans, J. J. M. Alons-van Kordelaar, T. M. Tadema and C. J. L. M. Meijer. Here is an excerpt: "Abstract - The occurrence and coexpression of the cytoskeletal proteins vimentin and cytokeratins were studied in malignant mesotheliomas and pulmonary carcinomas. For this purpose a double immunoenzyme staining with monoclonal antibodies was developed which made it possible to visualize vimentin and cytokeratins simultaneously within the same cell. A clear distinction between stromal cells (vimentin only) and tumour cells was also obtained.
A total of 12 mesotheliomas (six mixed type and six epithelioid type) and 13 carcinomas (eight adenocarcinomas and five large cell undifferentiated carcinomas) were studied.
The results revealed a clear difference between mesotheliomas and adenocarcinomas: 11 of 12 mesotheliomas showed coexpression of vimentin and cytokeratins in at least 50% of the tumour cells, while in seven of the eight adenocarcinomas none or only a few cells could be seen with this coexpression. In the undifferentiated large cell carcinomas three of five expressed both components, but in less than 25% of the cells. It is concluded that a reliable double immunoenzyme staining of vimentin and cytokeratins can be used as an additional means to distinguish malignant mesothelioma from pulmonary denocarcinoma."
About the Author
Monty Wrobleski is the author of this article. For more information please click on the following links